Quotable Quotes: Tei¢holz and Taube$
I normally only share this stuff on social media these days, but the hypocrisy and irony here is too much. This book is stocked full of ironic and just downright hilarious contradictions and inconsistencies. So many ... not enough time ... :-)
Kindle Location for Teicholz quote: 652-657
Comments
http://www.naturalhealth365.com/ketogenic_diet/cancer_part_4.html
Plus the not infrequent fun of the reader coming upon some choice comment or tidbit resulting in said reader laughing his arse off.
I found this fascinating:
Further, Madison showed (in 1964) that ß-OHB (and acetoacetate too!) decrease plasma NEFA's and blood glucose [in the dog] by INDUCING INSULIN SECRETION FROM THE PANCREAS. [emphasis mine] The blood level of ketones sufficient to produce this stimulatory effect on pancreatic ß-cells also "occurs during carbohydrate deprivation associated with either a high fat diet or complete starvation...The stimulatory effect of ketones on the pancreatic ß-cells...may modulate the release of NEFA from the adipose tissue, regulate the rate of ketone production by the liver, and thereby prevent the development of progressive ketoacidosis." [Leonard L. Madison et.al. The Hypoglycemic Action of Ketones II. Evidence For a Stimulatory Feedback of Ketones on the Pancreatic Beta Cells. Jrnl Clin Invest (1964) v43 (No. 3) 408-415.
Pretty sure I blogged on ketones stimulating insulin before. I'm curious as to the magnitude of the effect, as NEFA themselves are responsible for a fair proportion of insulin release in the postabsorptive state. In either case this the biggest problem for T1's. Incidentally, Jimmy Moore's wife has been seeing very high ketones w/o going quite to his extremes, and gaining weight and now diagnosed with "mild Hashimotos" ... The thyroid role in all of this is fascinating. Perhaps 2015 ...
To Cahill's credit, he saw the evidence and regarded it as important; to his discredit (in my view) he then sought first for pharmaceutical concoctions that would enable ß-OHB to be taken orally (as in a pill!) rather than the much simpler low-carb route.
While I too dislike how all too often the discovery of pathways etc. tend to be followed with "this is a potential target for pharmaceutical therapy", I don't think we should discount that either.
Achieving ketosis through diet is not always "simple" and even when one tries very hard, levels wax and wane, and the body does fight pretty dang mightily to stay OUT of ketosis. The diet to produce sustained ketosis is not without negative side effects. Therefore, and Attia was apparently quite stoked (vid shared by Ferriss) by some more current research in this area, being able to administer BHB orally or stimulate ketone production in the absence of aggressive carbohydrate restriction seems a worthwhile effort. Dietarily, MCT's seem a reasonable option as well, but most cannot tolerate high doses of these. Most Atkins dieters are in negligible ketosis after 10 weeks. In acute applications, the time to achieve ketosis is longer than the therapeutic window. Lastly, the beauty of pharmaceuticals, and it is a plus that is often downplayed by those seeking "natural" solutions at all costs, is that dose-response can be predictable, especially in this aspect were we're talking about ketone levels.
Bang on. The nail has been hit squarely on the head. Overconsumption as the chief culprit responsible for 1. the elevation of all the usual suspects [risk factors], and 2. the parade of pathologies that follows sooner or later.
Is one macronutrient the primary villain? I do not think that Mr. Taubes will be any more successful in his attempt to prove that carbs are a UNIQUELY fattening food than Mr. Keys was in proving that dietary saturated fat is a uniquely dangerous food. Of course, if Mr. Taubes does manage to refute a Law of Thermodynamics, this would most likely get him on the cover of Time Magazine--just like Ancel Keys! You were right on target in instantly nailing Mr. Taubes for the same [unscientific] hubris that low-carb folks attribute to Keys--i.e., jumping the gun and asserting in full confidence that their hypothesis is so clearly correct that it must henceforth be taken as the true explanation--unless proven otherwise. Two cases of a different kind of surfeit--boundless personal ambition.
With respect to "nuttiness": Charles Grashow recently posted a link to an interview of Wm. Castelli [of Framingham Study] by Kirk Hamilton. As many do, Castelli in 2011 still buys the whole Diet-Heart package as was wrapped and sold since the early 60's. Castelli praised Hamilton for his own "prudent" breakfast of champions; to wit: a bowl of mush and bean juice. [ugh].
Are carbs evil? No they are not.
Is this a "nutty" breakfast? I'd say so!
Is dietary saturated fat evil? No it is not.
Is eating a stick of Kerrygold a "nutty" breakfast? You betcha!
Neither (in my judgement) is "prudent" because while neither is poison, neither is likely to "buy" those eaters that extra margin of healthy longevity that is being "paid" for by choosing to glug down such unpalatable stuff.
I do not worship the ketone. But neither do I think that having a few circulating in your blood is "nutty" [and I know that you've written of the situations where you think they have therapeutic value].
Agreed: 80% fat calories IS "nutty". But for the same reason 80% carb calories is an equally uncalled for extreme, and hardly "CARB-SANE."
The really fervent Ketopians are as much out-to-lunch as the Vegangelicals.
on her blog, and he's a very interesting man. Lots of good, quality
content there.' I have a suspicion as to where we might see some of Ms Culpepper's comments popping up next :-/
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