The Carb-Sane Asylum

Previous post:   Insulin Dynamics I - Secretion vs. Sensitivity in Health & Disease/Decline This post will discuss the following paper:   Development of hyp erinsulinemia and insulin resistance during the early stage of weight gain  (Erdmann). This was yet another paper I came across thanks to this recent review: Body Weight Regulation and Obesity: Dietary Strategies to Improve the Metabolic Profile .  I'm efforting the full text of this that I can share here, but in the mean time, here's the context in which the Erdmann paper is introduced in that paper: Overweight and obesity represent a worldwide increasing health problem that seriously raises the risk for the development of severe metabolic disorders such as type 2 diabetes (T2D) mellitus and cardiovascular diseases (Erdmann et al. 2008, Klein et al. 2004). As with increasing obesity, insulin action decreases, and the system usually compensates by increasing β-cell function and consequently insul...

Continuing on in this series dealing with  the neuropathy study  from which the following statement has been repeated regarding blood glucose levels:   Nerve Damage Occurs when Blood Sugars Rise Over 140 mg/dl After Meals   (as stated by  Ruhl  , Jaminet  (Kindle Locations 712-716), and   Kresser .) At the risk of repetition, this does seem to have originated with Jenny Ruhl's interpretations of this study wherein 50% of 72 individuals with neuropathy were diagnosed as IGT having a BG level over 140 mg/dL at the 2-hour mark of an OGTT.   The IGT group was also more likely to have painful sensory symptoms than the roughly one-third who were normoglycemic (the remaining group were frank diabetic).