The Carb-Sane Asylum

Normally these days I'd put this in the library, since I'm not really going to blog on this, but I thought this paper a good one to share. Adipose tissue and adipokines: for better or worse In recent years, it has been recognized that adipose tissue (WAT) secretes a number of bioactive peptides and proteins, collectively termed “adipokines”.  These WAT-derived factors play a central role in whole body homeostasis by influencing a variety of biological and physiological processes, including food intake, regulation of energy balance, insulin action, lipid and glucose metabolism, angiogenesis and vascular remodeling, regulation of blood pressure and coagulation. The present review is focused on a restricted number of adipokines, which have been implicated in vascular (angiotensinogen, PAI-1) and energy and glucose homeostasis (ASP, TNFα, IL-6, resistin, leptin, adiponectin).  

Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans Get this one while its free folks (until the end of the month)!  Adiponectin is an all-too-often overlooked hormone in the obesity and metabolic syndrome game.   I haven't had time to read it thoroughly but it contains a wealth of information.  The graphic below summarizes the 17 page paper content: Hmmmm... cheers everyone!  (booze is adiponectin friendly :) )

I just came across the following article, and haven't quite digested the whole thing just yet.  Still, it is interesting so I thought I would share it here.  This post will be about the most curious topic in this paper, but I hope to revisit this in a series of future blog posts (hence the "I" in the title).   Adiposopathy Is a More Rational Treatment Target for Metabolic Disease than Obesity Alone Near as I can tell, the lead author, Harold Bays, is the doctor who coined the term "adiposopathy" or "sick fat".   Adiposopathy is pathologic adipose tissue dysfunction that may be initiated and/or exacerbated by fat accumulation (adiposity) in genetically susceptible patients [1••].  Adipocytes are metabolically active and adipose tissue is an important endocrine organ (Table 1) [2••]. Abnormalities of adipocyte factors contribute to dysmetabolism (Fig. 1), and adiposopathy [1••,3•] promotes some of the most...

Another "bookmark" post.  This is a link to a summary of Adiponectin research: http://scienceandreason.blogspot.com/2007/09/adiponectin.html

Putting this link here for future reference.  It's a full text article on this hormone produced by white adipose tissue that is associated with insulin resistance. http://care.diabetesjournals.org/content/26/8/2442.full