The Carb-Sane Asylum

I came across this one a while back and found it fascinating. The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects In this study, 8 overweight/obese individuals (4M/4F, 30-60 y.o.a., BMI ≥ 27, otherwise healthy) were treated with a very low calorie diet (500 cal/day shakes + unlimited veggies) for 5 weeks followed by a weight stabilizing diet for 3 weeks.  Abdominal subcutaneous fat biopsies were taken before and after the 8 week intervention.   There's a lot more here than what I'll address in this post.  I hope to return to this at some future date, but in keeping with this series, I want to focus on the fat storage portions of the study.  I have quite a bit in the pike regarding fatty acid transport and storage in various cell types.  While fatty acids can be transported into (and out of) cells by passive means, it became apparent to me a while ago that the relatively rapid cl...

Before some of the recent commotion around here, a blog post entitled Let's Play Concentration   caught the eye of Paul Jaminet over at Perfect Health.  His commentary then inspired me to write  Glucose and NEFA: From Dysfunctional Metabolism to Toxicity .   In the comments section Paul and I got into a discussion about free fatty acid (NEFA) clearance from circulation.  It seems that this is a subject of a lot of uncertainty.  Indeed when I first started looking into this stuff, way back when, I kept coming across statements like that insulin was required for fatty acids to be taken up by fat cells (three guesses where that traced to and the first two don't count ...).  My inner geek was prompted to look back into this.   This topic is of interest to me as my regular readers are well aware of my near-obsession with NEFA.  {grin}