I encourage all of my readers to go check out:
How the "Black Age" of Endocrinology May Be Affecting Your Understanding of Insulin Resistance & Obesity
I'm still mulling over the ramifications of, in particular, her second link that applies more specifically to insulin. A major point of the article is that insulin's inhibitory actions are likely more important than it's stimulatory actions. This ties in with my research on NEFA's and concerns over the impact of VLC/HF diets on NEFA levels and whether or not this is potentially detrimental. I'll blog on that in the near future.