... high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling.So I was poking around in my Downloads folder the other day and happened across this paper:
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes (I've cleaned up the excerpts from the citation #'s as I find them distracting)
Insulin resistance is a primary factor in the development of type 2 diabetes, and recent studies have implicated fatty acid activation of a serine/threonine kinase cascade in the pathogenesis of insulin resistance. Recently Yuan et al. hypothesized that IKKβ is a key downstream mediator in this process and demonstrated that high doses of salicylates, which inhibit IKKβ activity, reversed hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling .In short, IKKβ is an enzyme involved in immune pathways, blocking its action has beneficial effects on sensitivity to insulin.
Herein lies the quintissential chicken-egg debate. Which comes first? Inflammation or IR? In any case ...
This study involved 9 adult (avg age = 48), obese (avg BMI = 37), Type II diabetics (6M/3F). They were tested before and after 2 weeks high dose aspirin treatment (avg dose almost 7g/day). Baseline values served as control in this study (as opposed to a placebo group). The results for various parameters are shown below:
Two weeks of aspirin treatment resulted in a drop of about 40 mg/dl in fasting plasma glucose concentration, and this drop was not associated with any episodes of hypoglycemia. There was a small but significant decrease in creatinine clearance rate (12%) that normalized following discontinuation of aspirin. There were also significant decreases in concentrations of plasma cholesterol (15%), HDL cholesterol (10%), triglycerides (48%), and C-reactive protein (17%).In the discussion they add:
We found that a 2-week trial of high-dose aspirin treatment was accompanied by significant decreases in hepatic glucose production (22%), fasting plasma glucose (24%), fatty acids (50%), and triglycerides (48%) and a 19% increase in peripheral glucose disposal.
Wanna cheat on your next cholesterol test? Lots of aspirin and alcohol* just may do the trick!
* Raise that HDL, further lower the FBG