Science Krispies ... with a Tall Glass of Leptinade!
Yes folks, Science Krispies are best enjoyed with tall cold glass of Leptinade, stevia sweetened of course.
How do I know if I am "leptin resistant"?
Last week over at PaleoHacks, I've gotten to know a bit more about someone I'd heard much about on Jimmy's forum, but never really bothered to look into. Dr. Ron Rosedale, author of The Rosedale Diet. I have a post in mind on some of his claims but we'll see if it floats my boat to post it up. It was an odd coincidence that I was also skim reading through the copy of Nora Gedgaudas' PBPM book a friend bequeathed to me, and came across the section on leptin resistance, complete with referencing and a quotation from none other than Rosedale. And when at PaleoHacks, there's no avoiding "The Quilt", aka Jack Kruse Neurosurgeon! (Whenever I see his name I imagine some movie announcer booming Neurosurgeon! in action hero voice, with Jack as Dr. Evil flipping epigenetic switches on Mini-Me). Jack's stance on everything seems to boil down to either you're leptin resistant or you're sensitive, and all manner of things can be explained with this simple wave of the hand. Can't lose weight? Resistant. Eat 50g protein within an hour of waking and in a few weeks you'll be able to walk on water eating 10,000 calories a day of dark chocolate covered macadamia nuts while losing weight, all thanks to having reclaimed your leptin sensitivity! It's a wonderful philosophy to have because it explains everything!
I'm not going to sugar coat this, these three not only set my bullshit detector off rather quickly, but they peg the meter. There's a lot there, but let's talk this notion of leptin resistance in general for today. Now leptin resistance is certainly a legitimate recognized condition. Much like insulin resistance is. (Someday soon, we may be talking about ASP resistance ... yes, it's true!) But as with IR, there remains much to be learned (more for leptin because it was discovered decades after insulin) as to the mechanisms, causes, and what actually comprises "resistance". Consequently, there seems to be a lot of misinformation out there about LR, and thus it is a topic ripe for guru malarkey. So let's begin with what the Leptinade Triplets say about how one determines if they are indeed leptin resistant.
Oh ... I don't know. How about having leptin levels measured and see if you have hyperleptinemia? For all the self-diagnoses and treating going on around the low carb community, few seem to bother to actually know what's going on in their bodies. Indeed one of the knocks on scientists, and those of us who read and discuss their work, is that there's too much of a focus on studies and science and not enough about the reality of what is seen in clinical settings and such. That somehow the results in a metabolic ward do not extrapolate to free-living humans, as if somehow being confined in a controlled setting dramatically alters one's metabolism. But some genetic knockout mouse? Now that they seem to relate to. Me, me, me!! You can be obese w/o being hyperinsulinemic or IR. If you just assume ... well ... you know where that gets you.
How do I know if I am "leptin resistant"?
Any, but not necessarily all, of the following symptoms can indicate that you are leptin resistant:
... Any of this sound familiar?
- Being overweight
- Fatigue after meals
- The presence of "love handle"
- High blood pressure
- Constantly craving "comfort foods"
- Feeling consistently anxious and/or stressed out
- Feeling hungry all the time or at odd hours of the night
- Having osteoporosis
- Unable to lose weight or keep weight off
- Regularly craving sugar or stimulates (like caffeine)
- Having high fasting triglycerides over 100 mg/dL -- particularly when equal to, or exceeding cholesterol levels
- A tendency to snack after meals
- Problems falling or staying asleep
- Your body seems to look the same, no matter how much you exercise
Nora Gedgaudas, p. 149 Primal Body - Primal Mind
I must be leptin resistant. Oh wait. Since taking selenium I'm no longer LR as I'm sleeping better. Phew! How about Kruse?
The easiest way to do this if you are heavy is to look in the mirror. If you’re overweight you definitely are Leptin resistant. If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant. If you are fit or in decent shape and not sure based upon the above symptoms, I would tell you to go get a blood test and check your reverse T3. It will be elevated. I also recommend simultaneously checking a salivary cortisol level. With LR, you will always see higher cortisol levels later in the day.
Well, at least he recommends some tests, but the blue emphasis is mine. Now folks, we KNOW that there are a lot of overweight and even obese people who aren't insulin resistant. It's a bit of a stretch, then, to presume all overweight are LR. So following his plan:
Do you notice you sweat more and have less muscle fatigue when you exercise now? Have your carb cravings gone away? Is your hunger under control now? And are you waking up more refreshed?When these questions are all yes, then I push the button and tell them to start exercising more with intensity and duration first using weights but never using aerobics. The reason for weight lifting first, is that it generates less ROS in the muscle at the mitochondrial level, and more importantly that it stimulates the release of growth hormone to fire up muscle activity via the neuroendocrine system. It also more quickly reestablishes the Leptin sensitivity of the furnaces that our muscles contain to burn the fat we want to get rid of. As they improve, more weight comes off and the exercise plan increases. So far this plan has not failed me because it is not based upon my opinion. It is based upon our biochemistry that is 2 million years old! Most of my neurosurgical patients get this treatment before I will operate on them because outcomes are better when the patient is metabolically fit for recovery. If you are a patient who is Leptin resistant, and work too hard too quickly with exercise as you drop weight, the risk is generating too much ROS and depleting your stem cell supply. (Levee 17) The short term effect will be weight loss and a good result, but the long term effect may be faster aging and decrease longevity!
This is where the DigitalSurgeon and many trainers don’t see eye to eye. I don’t recommend conventional wisdom…….I rely on the knowns of biochemistry.
In case anyone is wondering what a levee is, this should clear it up. Here I thought they were something you found in Denmark and New Orleans. OK ... and in the comments section:
Carol asks: Yes, I’d like to see the biochem please… why do you recommend three meals w/o snacks rather than 4-5 small meals please? I can definitely feel my blood sugar taking a dive between meals if I don’t eat a sizable meal… and I never feel like eating that much at one time.
Jack responds: Why? my favorite question!…..4-5 meals consistently raises your insulin levels. Insulin is released biphasically, Short and long term. I would suggest you get a reference book like the biochemistry book link below to check this out. Anything that raises insulin chronically promotes fat storage when your leptin resistant and makes gluconeogenesis (glucagon) inefficient. Read my posts carefully, because the answer is already there. Your symptom is proof you have leptin resistance at your liver level. This information is in the leptin deux post! And it is contained in any biochemistry book on humans you find. The problem is diet guru’s make their recommendations on others opinions. I choose to go use evolution’s dictionary……2 million years of proven human biochemistry. And…….your blood sugar dives because you have hepatic leptin resistance and your liver cant stabilize your blood sugar because glucagon no longer is working. That can easily be fixed. You constantly eating just makes you worse because it increases your leptin resistance. (links to Lehninger biochem text)
Kruse loves to send people to basic biochem books to support his assertions. I've asked for specific citations for some of his claims and been told he's not going to do my reading/research for me. Okey dokey!! So, how about Rosedale? Take this Quiz!!
1. When you go on a weight loss diet, do you have trouble losing fat, that is, do you lose pounds but still remain ﬂabby?Hmmmm.... Guess we see where Nora got her list? Here's a few more I found:
2. Do you have trouble keeping weight off after dieting?
3. Are you constantly hungry?
4. Do you crave sweets?
5. Do you wake up hungry at night?
6. Do you have a “spare tire” or an apple shape?
7. Are you losing muscle mass despite the fact that you are exercising?
8. Do you feel stressed out?
9. Have you been diagnosed with high triglyceride levels?
10. Do you have high blood pressure?
11. Have you been diagnosed with osteoporosis?
- If you've ever watched Big Bang Theory on TV (reference to Rosedale's affection for cosmology)
- If you've ever had a nubbin.
- Were you born on the first Monday, second Tuesday, third Wednesday or fourth Thursday of any month?
- Is your index finger longer than your ring finger?
- Is your ring finger longer than your index finger?
- Have you ever wanted to get a tattoo?
- Have you ever wanted to pierce your body?
- Do you have saddle bags?
- Can you not eat just one Lays?
- Were you bottlefed?
- Do you get tired while food shopping at the end of a long workweek?
- Do you like to listen to loud music?
- Do you like pina coladas?
- Do you like getting caught in the rain?
- Do you like making love at midnight?
- Can you name the artist responsible for those last three questions?
- Are you pigeon-toed?
- Do you walk like a duck?
- Do you quack like a duck?
OK ... enough of CarbSane being silly (don'tcha just love the 3rd person?) and making shit up. Here's my point. These lists are nonsensical, especially when you say "any" or "just _____ (fill in with some small number)" of a long list of general things. So a bunch of people will follow these plans that are VLC, lose some weight, see improvements in things like triglycerides and IR (during and following weight loss). And two of these three have MD after their names so they must be speaking truth to power and all that jazz.
Pass the Leptinade!