Virgin Leptinade Poisoning! Last Glass of the Stuff!!

This will probably be the last post, other than perhaps dumping articles over in the library, regarding "leptin spikes".  And I don't normally link to and discuss abstracts, but in this case the abstract says it all.   Over on Mercola's hatchet job on starch, as discussed in my previous post, Ron Rosedale MD provided that science he's supposedly bridging over into medicine to support his contention that carbs "spike" leptin.  Here was the first comment addressing yours truly:
Because you do not know the science, does not mean that it doesn't exist. This is over 10 years old.  There are many articles subsequently that support and verify this. "Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes" Endocrinology,1998 Feb;139(2):551-8 "We conclude that glucose transport and metabolism are important factors in the regulation of leptin expression and secretion."
His repetition of the citation later in comments is illustrative of Rosedale's debate tactics.  The strategy is to (a) allude to a wealth of research supporting one's opinion, (b) cite one study that appears to support one's contention but not really, and (c) repeat as often as necessary using the same one cite, and apparently (d) hoping nobody will notice that the "many articles" and "robust evidence" has never materialized.  I've called him on the in vitro  study previously, and it is amazing the ease with which one can assemble a landslide of research that demolishes his claim.  I'm going to leave you with this last one:

Title sounds a bit daunting, no?  It's poorly worded, IMO, because it seems to imply that leptin does peak in non-diabetics in the postprandial state.   Here's the abstract, and I think you'll see from the get-go why I'm bothering with it.
Leptin production by the adipocyte is acutely stimulated by insulin in vitro.
Cue the Meatloaf:  Stop right there!  Before you go any further ...  Apparently this is what Rosedale did once he found his in vitro studies, and wants his followers to do as well.  Because his 1998 paper showed just this.  Only a short three years later, that would make this study a decade old (ground-breaking??), we have: 
In normal individuals, postprandial insulin peaks are not accompanied by corresponding changes in circulating leptin.
This, my friends, is Rosedale's G3P moment.
Postprandial regulation of leptin in individuals with type 2 diabetes, to our knowledge, has not been previously examined in detail. We examined the effect of meals on circulating leptin levels in six patients with type 2 diabetes who were not treated with insulin and in seven normal individuals. After informed consent was obtained, all subjects were admitted to the General Clinical Research Center for 6 days. They consumed four meals daily (breakfast, lunch, dinner and snack). Eighteen blood samples were drawn between 7 .40 a.m. and midnight for the determination of serum leptin, insulin and glucose levels. 
As if the first statement weren't definitive enough:
Postprandial peaks were clearly identifiable for glucose and insulin levels both in normal subjects and in those with type 2 diabetes. However, no postprandial peaks of leptin levels were present.
The rest of the abstract:
Correlation analysis demonstrated a lack of correlation between leptin levels and the levels of glucose or insulin. We conclude that, in spite of the presence of postprandial insulin peaks, there are no acute changes in circulating leptin levels postprandially in patients with type 2 diabetes who are not on insulin therapy.
The final sentence is not good news for a self-described diabetes expert -- internationally known! -- who says it's ultimately all about the leptin.
In this regard, in-vivo regulation of leptin by meals in patients with type 2 diabetes is similar to that in normal individuals.
"This is essential knowledge in designing a diet to control leptin and therefore health."  Oh wait, that's Rosedale again discussing what happens in a culture dish.  But Rosedale has "measured hundreds of insulin and leptin levels in people."   Shouldn't he know this then from his vast clinical experience??

Apparently (again in comments on Mercola):
Posted On Nov 25, 2011
I am writing 2 books. You can now keep updated from my website,  I had been helping out in India for several years. I had great times at Robert"s conferences, and I am glad that you were influenced. I am sure that Robert would have loved to hear that also. Thanks for the kind words.
Perhaps the book on the program he's designed from that "essential knowledge" is already too far down the line to completion to bring it back now.  Apparently leptin spiking by carbs is integral to the diet he's designed to bridge the gap between science and medicine.  Too bad he didn't look closely enough at all the groundbreaking work done this past decade or so.  But don't listen to me, I'm not sporting the "Expert" badge, I'm but a "Dissenter". 


Lerner said…
it seems like an irrational zoo over there, Evelyn. Which is what I'd expect, so to actually look today was rare for me.

But I did see just what you are saying.
Dawn said…
It's pretty rich to use a study that states "X" to try to support your theory of "anti-X." In fact, it assumes an alarming level of ignorance and stupidity among your followers. (They should be righteously offended!) Either that, or it reveals an even more alarming level of ignorance, stupidity (and illiteracy) on the part of the leader.
Sanjeev said…
I finally caved and decided to read some Mercola commenters.

and pretty soon the bell tolls

" I have much more to do than to try to educate a closed mind such as yours."


In my experience it's the MOST closed minded that raise this first.

With rare exceptions open minded folks never resort to this BS.
Thomas said…
From Mercola's site:

"So, to sum it up in the fewest number of words possible, know that:

Raising blood glucose raises insulin, which increases insulin and leptin resistance.

And avoiding insulin and leptin resistance is perhaps the single most important factors if you seek optimal health and longevity. Therefore, consuming more than about 80 grams of carbs per day, based on the research, cannot be recommended."

Based on the research....?

This is the kind of stuff that turned me against Mercola. Well, that and all the scaremongering.

Did Mercola throw Paul Jaminet under the bus? I can't really tell.
Archibald said…
"In short, in my opinion Mercola is a dangerous medical crank" -- Steven Novella, MD, Yale University School of Medicine, from "Dr. Oz Embraces Joseph Mercola", Science Based Medicine, January 19, 2011:

Wear your Dissenters Badge with pride, Evelyn!

Rosedale is not notorious enough to have caught the attention of the guys at SBM (and, in its way, that would probably annoy him).

I agree with @lerner that the comments section is a total zoo. @sanjeev...the bell tolls for trolls. Rosedale is just plain rude and unprofessional in his replies, resorting to caps/shouting. He must be delightful to sit next to at a dinner party after he's had one too many glasses of vino fino & gets even more full of himself.