The Carb-Sane Asylum

I've previously blogged on  the effects of high doses of salicylates, aka aspirin, and insulin resistance.  In summary from that paper/post: ...  high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling. So I was poking around in my Downloads folder the other day and happened across this paper: Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes   (I've cleaned up the excerpts from the citation #'s as I find them distracting)

I have just recently come across what seems to be a treasure trove of research indicating salicylates (e.g. acetylsalicylic acid aka aspirin) improve insulin sensitivity and lower blood glucose levels.  Much of the research is in rodents, but the glycemic lowering properties of this common drug are well known (apparently) and documented in humans, but seemingly ignored?   Here's one:   Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkß   (Full text is available with FREE registration for anyone interested.  You fill out name and they ask for phone/fax info but I left that blank and had no issues.) We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing   insulin signaling. Activation or overexpression of the I B kinase    (IKK ) attenuated insulin signaling in cultured cells, whereas   IKK  inhibition reve...