The Carb-Sane Asylum

Boyer - Interactive Biochemistry A screen shot of the Menu:

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans We previously demonstrated in the rat that long term exposure to fatty acids inhibits B-cell function in vivo and in vitro. To further assess the clinical significance of these findings, we tested in human islets the effects of fatty acids on glucose-induced insulin release and biosynthesis and on pyruvate dehydrogenase (PDH) activity. PDH is the enzyme thought to control the entry of acetyl CoA from glycolysis into the Kreb's / TCA /Citric Acid Cycle. These authors did an in vitro  study with human cells to see if the results compared with those seen both in vitro and in vivo  in rats.  While in vitro  observations don't always correlate with what we see in whole organisms, this did correlate for the rat.  Therefore it is reasonable to believe that the results of this experiment are applicable to human metabolism. Human islets were obtained...