Is Glucose Toxic to Cells? Answers from the LIRKO Mouse and More ...
![Image](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgLSQ4_M1sJAAcLt2Xo9_kERMEANvCRCIT8EHvaQJMygEoXeHeUFAMedHAvsMbyobRkCPFnBYf6Mpp8K_w0-2X3WCvQLirJ3Nu6XifwqTV6PEAM_v5zFbP-u4tVCzwmoPyIDefRJP6jb-Q/s320/c3ko+%2526+ob.png)
I briefly interrupt Thermodenialgate reports to revisit the LIRKO mouse. But first, a little fun blast from the past. A few years ago now I did a series on fat tissue regulation that involved various receptor and gene knockout mice. I had a little fun making (low graphics tech) characters out of Star Wars Lego figures. First came C3KO , a mouse deficient in acylation stimulating protein, ASP, production. Shortly thereafter came Obi No Leptinobi .