The Carb-Sane Asylum

Jimmy Moore was a relatively healthy, 230 lb man circa 2005-2006.  Despite his repeated lies to the contrary, he didn't just see his weight creep up a pound or two per month for 15 lb increases per year in the intervening years.  Still, whatever his path, he ended up back over 300 lbs in 2012 and went on his extreme nutritional ketosis fat fast diet.  He is now teetering at the brink of his former 230 lb goal.   Someone ought to remind him that he was a mere 3 pounds more than he weighs now in 2009, but he's clearly entered the pathological state where he believes his own lies.  He's currently on hiatus from podcasting to co-write a book with Dr. Eric Westman (who I can only think has taken leave of his senses) on cholesterol.  This would appear to be an effort on Jimmy's part to convince himself and others that his levels are peachy keen and perhaps even healthful.

This post discusses:   Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity, A Driver for Ectopic Fat Deposition? Fats are continually being cycled in and out of our fat cells.  In the obese, circulating free fatty acids (or non-esterified fatty acids), NEFA, are often elevated.  These are often accompanied by deposition of fat in non-adipose tissues, aka ectopic fat deposition.  This ectopic fat is implicated in various impairments of cell function and even cell death (apoptosis) that result in insulin resistance, beta-cell dysfunction, etc.  This is often referred to as lipotoxicity.   This study sought to determine if this lipotoxicity is due to excessive release of NEFA from adipose tissue or from impaired trapping by adipose tissue of the NEFA released from dietary fat.  This work is from Keith Frayn's group.  It might be worthwhile to read my blog post on  Frayn's paper on adipose tissue as lipid buffer. ...

I was a bit taken aback by the title on a recent blog post by Dr. William Davis at his Heart Scan Blog Why doesn't your doctor try to CURE diabetes? Dr. Davis paints the medical profession with a rather broad unflattering brush.   Are there docs out there who are more concerned about profit over your health?  Yes.  Are there doctor-drones who reflexively reach for the prescription pad?  Again, yes.   But I believe that most doctors -- and I know several since before they became docs -- do care about their patients and dole out advice based on what they believe to be the best course of action. Certainly the statement that " Adult diabetes is the one chronic disease that nobody cares to cure " goes more than a bit over the top! Davis goes on to say that most docs don't think it can be cured, and that is probably true.  The old school re: type 2 would be based on when the disease was more rare and probably not detected until progressed significantly to ...