Mitochondrial H2O2 Emission, Cellular Redox State and Insulin Resistance - Part I
Reader Ryan emailed me this link a while back and I've been remiss in getting around to it. Better late than never! Thanks for the link Ryan! Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans Mitochondrial dysfunction and oxidative stress have been implicated in the disease process, but the underlying mechanisms are still unknown. Here we show that in skeletal muscle of both rodents and humans, a diet high in fat increases the H 2 O 2 -emitting potential of mitochondria, shifts the cellular redox environment to a more oxidized state, and decreases the redox-buffering capacity in the absence of any change in mitochondrial respiratory function. Furthermore, we show that attenuating mitochondrial H 2 O 2 emission, either by treating rats with a mitochondrial-targeted antioxidant or by genetically engineering the overexpression of catalase in mitochondria of muscle in mice, completely preserves i...