The $12M NuSI/Ludwig Study: Part I: Critique of the Study Design
S UMMARY The results of the $12 Million Dollar NuSI-sponsored study, headed up by Dr. David S. Ludwig, are finally out. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial While the good doctor is making the rounds touting them as evidence in support of the Carb-Insulin Hypothesis (TWICHOO in these parts), a review of the raw data made available to the public casts grave doubts on his victory lap. This study built upon the "promising" results of the 2012 study: Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance This post focuses on comparisons of Study Design between these two studies, some improvements, and the ultimate failure that renders the primary outcome data suspect, if not outright useless. (And I don't say that lightly!) Improvements: Study size Length of time on one test diet (20 weeks) vs. 4 weeks crossover on each diet w/o washout Protei