S ummary: BUMPED January 26, 2018 This post was written around three and a half years ago, and through some bizarre twist of dietary fate, somehow ketogenic diets are still trending on Google for everything from weight loss to hang nails. So I thought I'd bump this post which was my attempt at dispelling some myths regarding ketosis and the role of dietary protein in the mix. In the end, and some of these points are not made specifically in this post but I'll make them here: Carbohydrate restriction is the greatest determinant of ketogenesis Protein (various amino acids) can feed into the Krebs Cycle and attenuate the reduction in oxaloacetate that favors ketogenesis from fatty acids. Ketogenesis represents a conversion of fat energy to ketone energy but it is not evidence of the ultimate usage of that energy. Like glucose, ketones will be burned for energy before fatty acids, so ketogenesis is not an indicator of actual fatty acid oxidation ("fa
Showing posts from January, 2018
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I am unsure why, but I am experiencing some problems with notifications, reading and posting responses to comments. This morning I posted one reply (I think, no notice it didn't go through) and then was unable to respond to another (kept getting some verification notice). In addition, I have been mostly on my phone as my computer screen cracked rendering it unusable until I managed to disable the touch screen. With that successfully disabled, it's a crapshoot if the unit turns on for limited use. I'm hoping Tuesday for my replacement. I would *REALLY* love returning to more regular blogging in 2018.
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S ummary: Diabetes, whether Type 1 or Type 2, is a dysfunctional, wasteful metabolic state. As a result, an uncontrolled diabetic either uses or loses more energy than their non-diabetic selves would otherwise use. As such, the untreated diabetic is essentially "underweight" compared with the body weight that the same energy intake would produce were they not diabetic. There are differences in endogenous insulin production between the two types of diabetes. In Type 1, there is effectively no insulin production. In Type 2, there is usually elevated basal insulin production, but a relative deficiency in acute insulin secretion, specifically an impaired early insulin response to glucose (GSIS). The absolute or relative insulin deficiency results in the following to a greater or lesser degree: Excessive lipolysis resulting in an increased cycling of the Triglyceride/Fatty Acid cycle. Impaired suppression of glucose production in the liver, specifically a