Fat Tissue Regulation ~ Part VII: Changes in Fat Cells with Weight Loss
I came across this one a while back and found it fascinating. The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects In this study, 8 overweight/obese individuals (4M/4F, 30-60 y.o.a., BMI ≥ 27, otherwise healthy) were treated with a very low calorie diet (500 cal/day shakes + unlimited veggies) for 5 weeks followed by a weight stabilizing diet for 3 weeks. Abdominal subcutaneous fat biopsies were taken before and after the 8 week intervention. There's a lot more here than what I'll address in this post. I hope to return to this at some future date, but in keeping with this series, I want to focus on the fat storage portions of the study. I have quite a bit in the pike regarding fatty acid transport and storage in various cell types. While fatty acids can be transported into (and out of) cells by passive means, it became apparent to me a while ago that the relatively rapid cl...