Intermittent Fasters might be interested in this.
METABOLIC ADAPTATIONS TO A "STUFF AND STARVE" FEEDING PROGRAM. I. STUDIES OF ADIPOSE TISSUE AND LIVER GLYCOGEN IN RATS LIMITED TO A SHORT DAILY FEEDING PERIOD
This is quite an old study, published in 1962, and it's in rats who are known to have greater DNL in adipose tissue. This was a fairly short study, wherein rats were put on a 2 hr/day ad libitum eating schedule for one week. Intake was 60% lower on day 1, but back up to 95% of normal ad libitum intake by the second day. Thus the rats lost weight early on, but were back within 10% of their start weight by week's end.
Essentially it appears that in short order with a switch to such a regime, adipose tissue storage and DNL in adipose tissue is upregulated considerably (10 fold). Normally a 24 hr fasted rat will have depleted glycogen stores as some is burned along with fatty acids. Rats adapted to this regime had full liver glycogen after the 24 hr fast indicating that they likely use fats preferentially for fuel.
Interesting ... not sure what it means in humans. But if something similar occurs, it could explain the insulin resistance many IF'ers seem to have, as non-oxidative glucose disposal -- e.g. glycogen synthesis -- is a major route of glucose disposal that is "defective" in IR states when reserves are high. Especially with LC, if glycogen is spared and glycogenolysis doesn't provide blood glucose, gluconeogenesis would be upregulated. The combo with hepatic IR may well be the reason why IF'ers often have quite high fasting blood glucose.
Maybe its not the fasting but the fact that people with those conditions will try fasting as a way to improve health.
No one with poor blood sugar control should ever try fasting.
Sounds like the typical low carb crap! "This is normal because...I'm low carb and things are different..."
May 6, "Eating for pleasure apparently has different effects on gastric hormones and neurotransmitter function than eating to live, Italian researchers found... No such increase was seen when, under the same conditions, the same volunteers were told to eat foods they didn't like but that had the same calorie content."
I have days where I eat most or all of my calories in a small window, maybe 6 hours or so. You can eat big and then be done with it!
Yup. Hard as it might be to believe, arriving at your goal allows more dietary freedom. Losing fat is in no way easy, but once its done you dont have to be as strict with your diet on a daily basis.
which we discussed here
I use the tool to get an idea of shapes and changes, not for absolute numbers.
On the right hand panel above the graph tick off "Advanced controls"
To the left of that, enter 3000 for "length of simulation" (tis is just to show very long term effects)
then above that input different sets of numbers for "First change" and "Second change" and be sure to set "Start change on day" for "second change" to 1500 or 2000
> arriving at your goal allows more dietary freedom
recipe for weight/fat loss disaster, IMHO.
If the diet WORKED, especially over let's 2 years, and keeps working, then the person, the diet and the lifestyle meshed. The best possible action would be to CHANGE NOTHING.
so there's no "stickiness" where one's reduced weight will refuse to change. You may be able to see some interesting dynamics if you initiate the second change on the active downside (instead of the stable end state) but that's
The only interpretation that makes sense of this fairly commonly repeated notion is that one diet down BELOW permanent goal weight then ease up on the diet, and hopefully the new higher weight is the permanent goal weight.
don't know why this got cut off ...
(instead of the stable end state) but that's not most people's' goal ... fiddling with weight loss dynamics to see interesting bouncing-around effects.
Given that they appear to be athletic, and that Martin does not favor LC, they are probably not LCing either.
Lean Gains is popular on a lot of low carb blogs but Martin refers to LCers as "The Taliban" so that's not what he has in mind.
Check the Hyperlipid blog on the subject of physiological insulin resistance. You can have higher fbs on LC.
Martin calls the fundamentalist variety "low carb talibans", re-read the article. He's not knocking low carb per se.
And he's had obese clients, see here: http://www.leangains.com/2010/04/leangains-inspired-bodyrecomposition.html
If so, it's interesting that the rat response is similar to the human fasting response which MAY BE INADVERTENTLY induced in some low carbers due to excessive carbohydrate reduction, as Jaminet addresses in his safe starch arguments.
Consider the patterns... the rats may be going into a pattern of periodic starvation. What do they do? They adapt by increasing insulin resistance in peripheral tissues, conserving limited glucose, presumably for nervous system tissues. Their glycogen doesnt get fully depleted overnight because of this induced insulin resistance. Adipose tissue gets upregulated... another energy conservation measure. This sounds a lot like the human fasting response. With respect to IF amongst the LC crowd... perhaps our glucose limitation is favoring a starvation response, and IF is only exacerbating the situation?
I was thinking that humans developed this IR response to starvation as an adaptation to ice age environments (I was going to reference her older piece, but when I searched, an update appeared... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253466/pdf/JOBES2012-258624.pdf?tool=pmcentrez), with periodic feast/famine cycles, but the maybe this response is well evolved in mammals probably much further back in time?
No conclusions here... just random postulation from someone trying to decode their personal health.
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