Welcome all seeking refuge from low carb dogma!
“To kill an error is as good a service as, and sometimes even better than, the establishing of a new truth or fact” ~ Charles Darwin (it's evolutionary baybeee!)
A while back, I made graphs of various oils' fatty acid profiles for my personal edification. The following graph has most of the oils carbsane mentioned, in a more visual format:
Thank you for sharing!
I am revisiting your blog. Few months ago I presented a view that ketone bodies play a unique role in human biochemistry, particularly in relation to the inflammatory pathways, (thus influencing CHD, T2D, Alzheimer's et cetera). You blasted me for it with both barrels - well, I guess that you'll say that Prof. Dixit and his team are a bunch of morons as well(p.s. I appologize for my broken, 5th-grade level English)http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3804.html
Evelyn, these molecular codes for various fatty acids are opaque and intimidating to a layperson like me. Wikipedia helps, but still…. Could you please amend your post with a fatty acid key?Thanks.
I'll try and see if the names match up on that website :-)
As I recall you visited the blog to "blast" me about thermodynamics and Krebs. I was alerted to that study (multiple times by the same person) on Twitter. Busy with other things at the moment so I don't have time to read it. Perhaps when I discuss ketones again here sometime, you'll revisit again.
"Christopher carbsane • 5 months agoDear Carbsane,Your statement:'If your diet helps someone with arthritis, it is almost assuredly nothing to do with ketosis and because they removed something they have a sensitivity too'is not entirely correct, although it is possible that change of diet eliminated a causative or supportive agent(s) for arthritis, however there exists a large body of research, basic and clinical, clearly showing that ketogenic diet through number of mechanisms (including ketone bodies) significantly ameliorates inflammation. Arthritis is an inflammatory disease. p.s.For the record, I do not follow any dietary regime, I just eat whatever takes my fancy at a spur of a moment."p.s. it was not me on Twitter, never used it, never will.
The fresh fat of the Walrus, slathered over the skin, has been highly regarded as a de-toxing agent for almost 3,000 years which makes it older than Socrates.The belief in the efficacy of the fat, I mean, not the Walrus itself, no Walrus can live for 3,000 years.
Christopher, the reason ketones suppress inflammation is probably because during starvation, normal processes of maintenance and repair need to be downregulated to conserve resources.Suppressing inflammation means suppressing the repair process. Non-steroidal antiinflammatory drugs are known to relieve arthritis symptoms without promoting repair, and indeed have been shown to inhibit it. We need to know whether this is what ketogenic diets do.
Jane, please read Youm et.al (linked attached to my first post) and the references it containes.
ediators Inflamm. 2014; 2014: 983401.Published online 2014 Apr 6. doi: 10.1155/2014/983401PMCID: PMC3997897BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-κB ActivationShou-Peng Fu, 1 Su-Nan Li, 1 Jian-Fa Wang, 1 , 2 Yang Li, 1 Shan-Shan Xie, 1 Wen-Jing Xue, 1 Hong-Mei Liu, 1 Bing-Xu Huang, 1 Qing-Kang Lv, 1 Lian-Cheng Lei, 1 Guo-Wen Liu, 1 Wei Wang, 1 ,* and Ju-Xiong Liu 1 ,*Author information ► Article notes ► Copyright and License information ►This article has been cited by other articles in PMC.Go to:Abstractβ-Hydroxybutyric acid (BHBA) has neuroprotective effects, but the underlying molecular mechanisms are unclear. Microglial activation plays an important role in neurodegenerative diseases by producing several proinflammatory enzymes and proinflammatory cytokines. The current study investigates the potential mechanisms whereby BHBA affects the expression of potentially proinflammatory proteins by cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS). The results showed that BHBA significantly reduced LPS-induced protein and mRNA expression levels of iNOS, COX-2, TNF-α, IL-1β, and IL-6. Blocking of GPR109A by PTX resulted in a loss of this anti-inflammatory effect in BV-2 cells. Western blot analysis showed that BHBA reduced LPS-induced degradation of IκB-α and translocation of NF-κB, while no effect was observed on MAPKs phosphorylation. All results imply that BHBA significantly reduces levels of proinflammatory enzymes and proinflammatory cytokines by inhibition of the NF-κB signaling pathway but not MAPKs pathways, and GPR109A is essential to this function. Overall, these data suggest that BHBA has a potential as neuroprotective drug candidate in neurodegenerative diseases.
I wasn't accusing you of being Patrick from Twitter, I was just saying I've seen it, just don't have time to read it in detail. When I get a chance to, if/when the topic of ketones comes up here again, I'm happy to discuss.
gotta LOVE that HUMAN intervention study and dat sweet, sweet TRILLION dollar FDA approval on this therapy, yeah? yeah ...
I never said that ketogenic diets do not have adverse effects in humans. I only pointed out that ketone bodies have anti-inflammatory propertiesyeah...
Also, please refrain from the strawman nonsense, OK? Moron is not a term I use in these types of discussions (though please do waste hours trying to find some isolated instance).
'please refrain from the strawman nonsense, OK?''please do waste hours trying to find some isolated instance'These two statements show me that:1) you have no clinical experience or access to the clinical data2) you do not have the slightest understanding of the scientific method
one more thing, you do not understand Youm et al paper and its ramifications.
How can I not understand something I have not had an opportunity to read? Keto is not on the top of my priority list, I'm sorry. If you would like to provide me with full texts of all studies you link to as well as your synopsis of what they say, this would be most helpful.
From reading the abstract it appears that Dr. Youm, et al. are suggesting a possible role for BHB in the suppression of a minor inflammatory pathway in mice. Whether this has any clinical relevance for humans has yet to be investigated. I'm too lazy to find your old comments to determine whether this was your original point or whether you were advocating for a substantially larger role for BHB in human rather than murine metabolism. If it was the former, than you have us dead to rights.
AND she's a girl.
so why you said; 'please refrain from the straw man nonsense' and 'isolated incident'OK a appologise for barking at you. I mean it. I can not post full PDFs because my set up does not allow me to do this. I am not keto. I work on biochemistry of inflammation and what we see is that, the ketones, when increased in plasma (by several means), alleviate many inflammatory symptoms in many patients. We are absolutely sure that the reaction we observe is due solely to the ketone bodies. In my spare time I will write a short synopsis with references (there are more that 80 papers showing the influence (positive) of the ketones bodies on human physiology) and send it to you.
you missed the sentence about human monocytes ?
A minor inflammatory pathway!?are there minor AND major inflammatory pathways Stella?. Is this what your imaginary husband,"biochemistry, PhD with couple of postdocs and whatnot" told you?
The comments here should be nested. I posted that comment to your original comment here where you said I'd call Dixit and his team a bunch of morons. That is what is called a strawman fallacy. So I asked you to refrain from that.
I'm doing it
Well, bless your heart! It's good to have you back again, blasting us! It's really very good of you to waste your time on us little people when you could be discussing biochemical arcana with your more learned colleagues. If you're raising a child with Muckle-Wells syndrome who is not responding to any of the available therapies, then presumably it's a major problem for you. It's always nice to see new potential therapies for rare genetic diseases. Dietary ketosis is an accepted therapy for some forms of epilepsy and this research suggests that there might be a possible use for the same therapy in Muckle-Wells syndrome. It does not, however, necessarily follow that dietary ketosis is a generally preferable choice for the average person or even that suppression of the inflammatory response is universally desirable.
Presumably "in vitro" as the next sentence starts with "in vivo".
Unfortunate nutritiondata doesn't have macadamia nut oil.. it's the one I use on everything! But I bet it's profile would be similar to that of avocado oil
http://nutritiondata.self.com/facts/nut-and-seed-products/3123/2This is for the nuts, the default serving works out to almost exactly 100g fat and if you click on the "more details" tab for fatty acids you'll see it. Not able to do screenshot for you at the moment. FA profile seems to favor the macadamia!
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