Insulin Injection Effect on Fat Tissue
I'm sure most of you are familiar with the picture of the unfortunate woman below from Gary Taubes repeated use of this picture in lectures. The top is a screenshot from Google Books of Endocrinology: An Integrative Approach, 2001, Nussey & Whitehead, page 31. At the lower right, I've copied the discussion of Box 2.8 from the previous page.
Now, here's a slide from an April 2010 lecture (~7:40 mark)
This is quite par for the course for Mr. Taubes. Nowadays he has had to drop some of the major reasons insulin via carbohydrate intake is fattening based on the overwhelming evidence against them existing in the scientific literature and textbooks predating GCBC. The first to go was the ("" are to delineate phases, not direct quotes) "up to 30% of carbs in a meal is converted to fat", "excess carbs are turned to fat", and "de novo lipogenesis of fat from glucose that is taken up by fat cells into fat" memes. This one fell by the wayside fairly quickly in his lectures. The "you need carb to store fat", "alpha glycerol phosphate rules", "carbs increase G3P increases esterification" memes took far longer to excise (because removing this gutted his hypothesis).
And yet we still see the picture of this woman with more or less of a caption accompanying it. It is critical what Taubes chose to leave out of the caption on his slide. The fat accumulation in this woman injecting supraphysiological levels of insulin into her thigh fat, repeatedly, without proper rotation to other sites, for almost 50 years produced the rather disfiguring fat distribution. But Taubes left out the explanation from the textbook:
Whilst this was likely to have been caused by de novo lipogenesis from glucose, it is generally believed that on a Western diet, triglycerides are usually accumulated in adipocytes by uptake from plasma.
In other words, local injection of insulin likely stimulated de novo lipogenesis in the adipocytes in the area, thereby creating fat from carbohydrate and accumulating fat in these cells. The text authors are quick to point out that this is not analogous to the normal processes by which fat tissue grows in the intact human eating a (fattening) Western diet. This woman's fat did not become "lipophilic" sucking fatty acids out of circulation. The localized injections stimulated a metabolic pathway not quantitatively significant by endogenous stimulation.
Yes, this is a relatively small quibble. But the sheer number of these quibbles alone, leaving aside the major mangling of the science, is staggering.