Dear Incestral Health Community ...
You know who you are.
Please ... I have but one favor to ask. Can you just stop making shit up? That's all. It's simple. If eating a particular way works for you, then say so, and be done with it. Don't go making up scientific "facts" for why when you just made it up. Really, it's OK to believe that turtle toenails added to your mammoth toe jam smoothie improves your brain function if you want to. It's fine with me if you think adding a half a stick of butter and a glob of coconut oil to your coffee is healthy, but a packet of sugar will kill you. Go right ahead and believe you're a ketoadapted obligate fat burning beastie caveboymanchild if you insist. Be my guest and believe that grains rot your brains, wheat swoles your waist and gluten is Satan's excrement. Just stop scamming other people with this nonsense in the name of science.
P.S. I know I said one favor, but while I'm asking ... Could you also quit using ridiculously inane reasons to avoid particular foods and such? Seriously, if you have to resort to "you can blow up a rat's intestines feeding it raw beans" style arguments to convince people legumes are toxic, you need to find another line of work.
Some but not all patients with gluten sensitivity experience digestive symptoms, such as:
Other patients only experience symptoms in other areas of their body, such as:
Frequent infections (viruses, bacteria, and/or yeast) in any location (sinuses, bladder, skin, or other location).
Pain such as headaches, migraines, joint pain, muscle aches, fibromyalgia, and/or pelvic pain.
Neurological symptoms like dizziness, tingling, numbness, and weakness.
Mental/emotional symptoms such as brain fog, decreased memory, lack of focus, anxiety, depression, PMS, mood changes, and sleep issues.
Skin rashes such as hives, eczema, acne, rosacea, dandruff, warts, and psoriasis.
Autoimmunity such as Hashimoto’s, Lupus, M.S., Rheumatoid arthritis, Ulcerative Colitis, Crohn’s, and others.
Other common health issues association with gluten sensitivity include:
Weight gain or difficulty losing weight
Nutrient deficiencies (iron, vitamin D, B vitamins, and others)
Did they leav ANYTHING out??
I did a bit of a horizontal mushroom cloud in an elevator yesterday
So quietly I don't think even the MDA forums have caught it yet. They seem to have come up with plenty of other reasons why beans are bad though, including "empty calories" (butter and bacon are such micronutrient powerhouses in comparison, apparently) and autoimmune whatevers. So this probably won't matter to them, although it does set up a loophole for legume rehabilitation later should Mark find it expedient.
I've had a generally good time reading your blog and Twitter for a while now, and you've helped me un-brainwash myself from low carb "science," but not all paleo talking points are outright lies. There's at least a small grain of truth, however mischaracterized, in leaky gut, which you proudly proclaimed to be a made up disease on Twitter. That came as something of a surprise to me considering almost everything I research relates to intestinal permeability, endotoxemia, innate immunity, and the resulting low-grade chronic inflammation. Transepithelial electrical resistance, tight junction proteins, toll-like receptors, endotoxins; these are all myths? Can you link to that one paper which definitively shows everything I've been reading is just made up bullshit lies? Or have you been stuck in the armpit of Pubmed reading about insulin secretion from beta cells instead of researching important issues like inflammation and the etiology of obesity and chronic metabolic disease?
I find it wholly ironic that you completely discount a line of research you would absolutely love. If you think you have scientific ammo against the low carb community now, do a search for "metabolic endotoxemia" or "high fat AND gut flora". You seem to be so stuck in debunk-Taubes mode that you've missed the forest for the trees. If you really want to talk about science and direct the conversation in a more interesting and productive direction, have a look at the recent literature on innate immunity and low-grade inflammation. Cordain jumped on the intestinal permeability and endotoxemia bandwagon early, if you've ever read The Paleo Diet, which is most of the reason for his seemingly random food restrictions, and there's been a lot more research since then, and surprise surprise, it does not vindicate high fat diets. It really bothers me to see you so blithely dismiss such a fascinating area of research simply because of the messengers.
BTW remember when I was trying to come up with terrestrial food sources with a positive Omega 3:O6 ratio? Check this out: per 100 g --
Australian lamb, foreshank (lean + 1/8" fat): O3 178 mg - O6 375mg (1:2)
pinto beans, cooked, without salt: O3 137mg - O6 98mg (1.4:1)
kidney beans, cooked, without salt: O3 301mg - O6 191mg (1.6:1)
Greens of course come out best, especially the brassicas and chenopods:
Brussels sprouts, raw: O3 99mg - O6 45mg (2.2:1)
Spinach, cooked: O3 92mg - O6 17mg (5.4:1)
The first link is about inflammation and macrophage infiltration. I'm not really sure what you're asking and what that has to do with leaky gut. Adipose tissue secretes various inflammatory adipokines.
I do not believe dysbiosis has been causally linked to obesity except with the germ free mice. There was a study in humans in Sweden a few years back where glucose tolerance improved. I have never been able to find it for the long term followup -- whether weight loss eventually took place and/or glucose metabolism improvements held. My gut (get it?) feeling is that there is not a causal relationship dysbio -> obesity, and rather is the effect of overnutrition and obesity -> dysbio. This likely plays a role in glucose metabolism via the incretin system.
I guess I'd have to ask you how going on a PSMF or early insulin treatment would reverse diabetes if it were caused by dysbiosis. GBP too, though possible antibiotics could play a role (doubtful such a predictable one though).
I'm kinda swamped with other stuff at the moment to delve into the gluten thing. Hope you understand.
Take your time with the gluten study. I'd be happy if you discussed it at all. It ties in with this other research.
Human gut microbiota plays a key role in the development of obesity. Intestinal flora can regulate energy absorption and nutrition metabolism, increasing the energy harvesting from diet
That's an awfully bold statement that I think was made far more definitive than intended by translation. If not, then they should have been called on it.
The problem with this is energy absorption and good vs. bad, etc. If you have more good bacteria, you may absorb a small amount more energy. If you have more bad bacteria, THEY may "burn" a small amount more energy and you fart methane.
Humans are not rodents. We are not hindgut fermenters. This is a big issue.
MOre later, but you are confusing intestinal permeability with "leaky gut". IP doesn't mean that undigested matter and bacteria get into the blood stream. Find me some studies showing elevated lectin levels in the plasma of humans suffering from various illnesses. Do such exist?
Everyone must bow to to the intellectual might of former laboratory technician and junior college mathematics tutor Evelyn because she has read some outdated undergraduate textbooks. She KNOWS that she is always right and everyone else is a fraud. No room for nuance. Don't bother reading any research published after 2000 because the 1990s textbooks are infallible scriptures. The facts are set in stone.
In the world according to Evelyn food is burned directly in the mitochondria - no need to worry about all that tricky anatomy and physiology. No one is intolerant to any plant protein and all gut and metabolic diseases are mere hypochondria.
Don't worry about fact checking because everyone (actually only Evelyn) knows that ALL cells use glucose and it is a myth to claim that any cells use fat for primary metabolism. The textbooks are all lying when they state that cardiopmyocytes use lactate and FFA as their primary (80%) energy source or that colonocytes rely on SCFA for energy.
The gut microbiota don't count because humans are not animals. We are engines that burn fuel according to a simple textbook formula.
Cordain - PhD Exercise Science -- not nutrition, and certainly not anthropology
Kruse - ????? Seriously? Jack Kruse. Exactly what that I have written about how off the wall this guy's ideas on nutrition and "quantum biology" are you complaining about?
Peter? - He's a vet, not a physiologist. He also routinely manipulates data and misrepresents things.
Eades? - His undergrad background was civil engineering or somesuch. It's no surprise he misrepresents things incorrectly as a matter of routine.
Shou Ching Jaminet - LOL - When I hear HER discuss the diet in the book that bears her name we'll chat. As it stands, it is a man with a PhD in applied physics that is doing the nutritional talk and his research skills leave much to be desired.
Emily Deans - I don't recall every challenging her one way or the other on science ... she doesn't write much about it and I'm not particularly interested in evolutionary psychiatry.
They are all qualified to comment, but it helps if they get things right, no? Instead of just making shit up or ignoring large swaths of contemporary research and research done by scientists in the various fields?
Now, as to your characterization of me as a former lab tech, you are mistaken. I have over a decade of real scientific research under my belt and it is obvious that most of the "big names" including one "former research biochemist" have done little if any such research. What is Cordain's *primary* research record? Not ethnographic atlas smoothiepology. Actual research?
Outdated text books? Are you for real? I'm not the one who cites 1960's texts or who wrote a book with less than 1% references post 2000. Are you reading he same blog I'm writing? I mean most of what I blog on here is post 2000, much of it post 2010. I have a collection of text books that are generally newer than 2005 as well, though it is remarkable how well *SOME* of the older ones hold up under revision.
Please don't put words in my mouth about metabolism. You are hopelessly ill informed as to my opinions and knowledge as you are in general based on your commentary I've read over the years. I did not say gut diseases were hypochondria. You said that. I have said that "leaky gut" as put forth in the alt.med. community is quackery. How about they start with something simple. Can we measure levels of these substances or antibodies to them in people so afflicted? I haven't seen much on this. There's a doctoral thesis out there for WGA that indicates otherwise. Others are free to read, distill and disseminate information. DON'T MAKE SHIT UP.
Where have I EVER stated that there are not cells that do not use glucose as primary fuel? Heck, Kresser links to a paper I put in the "library" here about lactate, and I tweeted this out a little while ago https://twitter.com/CarbSane/status/456384248459440128
I've made quite a few posts here on SCFA ... did you miss those? I didn't say gut bugs don't count, but several detailed analyses have determined that in humans they play a minor role in energy balance. Perhaps rather than trolling here you could help me find the Swedish (I believe) study where they did fecal transplants in obese diabetics a few years back. At the time there was some improvement in glucose metabolism but no weight change. There was mention of followup -- never heard more. Does the almighty blogblogBris have a clue what I'm talking about? Care to expend some skull sweat to help me out rather than pissing on the floor here? Thanks!
Don't worry about fact checking? As you can see with me letting your stupidity through, I welcome challenges here and if someone wants to engage me on the facts I'm always open to that. Somehow they'd rather kvetch for days over what size pants I wear or why I don't post selfies every other day.
Regarding your above comment about the adverse effects of a high-fat diet, would a diet providing ~80% of energy from fats (but free from gluten & lectins) be any cause for concern?
As for autoimmunity, that's exactly what happens in celiac disease. Gliadin binds to tissue transgluttaminase, which triggers the autoimmunity. I'm not sure if any other lectin would have that effect. And I'm not sure how it would to allergies. Sorry.
I was wondering about the effect of excessive IP on AI diseases other than coeliac disease, such as Eczema, Dermatitis herpetiformis, Sjögren's syndrome, Cerebellar ataxia, Multiple sclerosis, Type 1 Diabetes, Rheumatoid arthritis, Asthma, Lupus erythematosus, Autoimmune thyroiditis, LADA etc.
By allergies, I meant the rapid adverse reaction to a repeat exposure to something e.g. peanut protein.
There's research on the hygiene hypothesis/parasitic infection and autoimmunity/inflammation, which I think down the line is going to be very illuminating.
Food allergy is a tough issue and ultimately may be unavoidable.
Sorry I couldn't be of more help.
Cordain has it wrong regarding the inflammatory potential of cereal grains. We've been eating grains for thousands of years prior to any uptick in autoimmunity. Now gluten from the modern wheat could be involved in the increasing incidence of CD. However, it's not implicated in any other autoimmune issue. Having said that, since IP does seem to reign if you are autoimmune, most people claim their symptoms improve when they stop eating gluten and dairy, where supposedly casein is similar in structure to gluten and give rise to antibody attack from molecular mimicry. Now that's the whole rationale behind the autoimmune protocol that calls for eliminating gluten and dairy.
I have no problem with this autoimmune protocol when food elimination is limited to the offending agents. I have a problem when these Paleo and low carb morons start cutting out all carbs as part of such protocols, as carbs are "inflammatory." If you cut out carbs when you're autoimmune, you will directly affect mucosal immunity and put stress on your thymus, potentially affecting t lymphocyte functioning. That could not only lead to immunodeficiency but further proliferation of autoimmune issues. If you have RA, for example, the next issue that will piggyback is Sjogren's, then Lupus, then Hashimoto's, then T1. Cordain knows zero about autoimmunity. Terri Wahls is a GP who's only authorized to treat veterans. She's doing a great deal of harm because if an autoimmune follows her ketogenic AI protocol, the weight loss-induced reduction inf metabolic inflammation will temporarily abate autoimmune inflammation. Over time, that will worsen symptoms and enable other autoimmune issues to piggyback. She's lucky she's not treating any autoimmune patients, else her ass will be sued and quarterly antibody tests will show that her diet is worsening, not improving, autoimmunity.
But it's not just my perspective that changed, it's the perspective of the whole community. Check out the resistant starch cult and the influence it's had. A newbie to the Primal Blueprint can't quote Mark's old blogs or his book on his own forum without being run out of town. Maybe you're right about immune suppression, and I know the gut and the immune system are closely linked, so maybe I'm just arguing the other side of the coin, but this all reads like needless scare-mongering. Either way, I don't support a typical low carb paleo diet. :/
But it's my understanding through research that it's the high fat intake that would have the largest impact on the immune system and inflammation through greater endotoxemia than you would see from a high carbohydrate intake. Is this only half-right? Logically, eating less fat and more carbhoydrates would reduce endotoxemia and inflammation, which would resolve the Raynaud's phenomenon, but in that scenario, it's the reduction of fat that would be therapeutic.
I guess that's pretty much the same question. Could you fill in some gaps in my general knowledge?
Having said that, most people become autoimmune via SAD. Most autoimmunity starts with genetic factors and metabolic symptoms frequently accompany the onset of Hashimoto's or RA. In fact, you can say that about 50% of the American population has autoimmunity or is in the process of developing one. Autoimmunity and immunodeficiency are notoriously difficult to diagnose. You need a specialist and even then until you start showing clinical symptoms, you're on your own and that's why Alternative Medicine is thriving. What VLCing does is get you over the hump; it could accelerate the manifesting of clinical autoimmune symptoms, could directly be linked to T lymphocyte dysfunction.
Art Ayers is a low-carb PhD but started acknowledging this recently.
"I was shocked to learn that there were some paleo (meat and veggie) eaters who were getting cured with resistant starch. I didn’t know that some were sick and, as I said in a previous post, I would not have guessed that starch was good for anything, but spikes in blood sugar ... People get sick on paleo, because they don't feed their flora. Gut flora are needed to supply vitamins, short chain fatty acids and immune system stimulants. If you don’t feed your flora you get vitamin deficiencies, gut inflammation and autoimmune diseases (Treg deficiency). It is very important to remember that feeding your flora means matching the soluble fiber with the existing flora. Many people lose species of gut flora as they change from diet to diet, eat processed foods lacking soluble fiber or use antibiotics. The loss may be permanent, but need not be. Food intolerance and most “allergies” merely reflect missing species of bacteria, and introducing new bacteria fix the problem. Lactose intolerance, for example, can be cured by eating live yogurt. Similarly, many immunological problems, such as autoimmune diseases, result from species of gut bacteria that are needed for the development of the immune system, which takes place in the lining of the gut in response to gut bacteria. New bacteria need to be introduced to fix the deficiency and diet alone is not enough. ... Just to be clear; meat-exclusive paleo can lead to autoimmune diseases, because of deficiencies in gut flora diversity/species and adding back soluble fiber can only cure the diseases, if the bacteria needed to digest the fiber polysaccharides are still present or are reintroduced."
Like I said, you don't need the gut flora angle to establish all this. The evidence was there before. We have the statistics from the patient populations of the Eades, Bernstein and Cordain's own comments which show that there indeed is a huge skeleton in the LC closet.
*with the admission that leaky gut approaches something resembling out of context truth.
My general tips for IBS, though, if you're interested: Drink luke warm/hot water with lemon juice, eat oatmeal, adhere as well as you can to a proper day/night cycle, and reduce psychosocial stress. A poor lifestyle usually punishes me more than a poor diet. Diet-wise, I can tolerate rice, potatoes, pineapple and plantains as my primary carb sources.
Previously only trip tans could abort his migraines. Now, adherence to a Ketogenic diet has relieved him of migraines
Please offer insight as to why that is. Perhaps I can optimize his diet even more
This means that you actually burn fat by eating Coconut Fats (including coconut milk, coconut cream and coconut oil).
These 3 studies from major medicinal magazines are sure to turn the conventional nutrition world around!
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